Proteomic insights into platelet dysregulation and pathogenic mechanisms of chronic thromboembolic pulmonary hypertension
Platelet aggregation and activation in CTEPH encourage the formation of NETs, which advances the disease and prolongs thrombus. Right heart insufficiency and hemodynamic markers had a strong correlation with PAD4 and NOX2 levels, indicating that these biomarkers may be employed to assess the severity and prognosis of CTEPH disease and offer a fresh approach to targeted treatment. The results highlight the need for additional study to elucidate platelet-mediated pathways and create therapies for CTEPH that target platelets.
Authors
- Yuhan Li
- Han Tian
- Qiang Huang (ORCID: https://orcid.org/0000-0002-5949-1225)
- Zhenguo Zhai (ORCID: https://orcid.org/0000-0002-7096-8792)
- Shiqing Xu (ORCID: https://orcid.org/0000-0003-4896-2930)
- Yishan Li
- Kuangxun Li
- Peiran B Yang (ORCID: https://orcid.org/0000-0002-4635-1215)
- Jixiang Liu (ORCID: https://orcid.org/0000-0001-6904-320X)
- Xiaofan Ji (ORCID: https://orcid.org/0000-0002-5433-9152)
- Min Liu (ORCID: https://orcid.org/0000-0002-8740-6622)
- mengjie Duo
- Ran Miao
- Zhu Zhang (ORCID: https://orcid.org/0000-0002-0635-8260)
- Jie Li (ORCID: https://orcid.org/0000-0002-6513-5702)
- Haobo Li (ORCID: https://orcid.org/0000-0002-1882-5831)
- Jing Wen
- Xincheng Li (ORCID: https://orcid.org/0000-0001-5159-7036)
- Lu Sun
- Ximei Niu
- Wanmu Xie (ORCID: https://orcid.org/0000-0002-6686-3517)
- Bingzhang Zou
- Jinzhi Wang
Institutions
- Nanchang University (CN)
- Xinjiang Medical University (CN)
- Shanxi Medical University (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Tumor Hospital of Xinjiang Medical University (CN)
- Wuhan Sixth Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12967-025-06891-8
- Citations
- 2
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- National Key Research and Development Program of China