EDC4 enhances multi-drug chemosensitivity in pancreatic cancer via GR50-based profiling
PDAC cell lines exhibit distinct chemoresistance capabilities. EDC4 and its downstream targets MATN3 and SGCE play significant roles in PDAC multidrug chemoresistance, providing novel insights for treatment.
Authors
- Zeru Li (ORCID: https://orcid.org/0009-0007-7101-2702)
- Jiashu Han (ORCID: https://orcid.org/0009-0007-4000-9893)
- Bangbo Zhao
- Yutong Zhao (ORCID: https://orcid.org/0000-0001-6604-9315)
- Lin Chen (ORCID: https://orcid.org/0000-0002-9196-3640)
- Cheng Qin (ORCID: https://orcid.org/0000-0002-4424-2410)
- Qianqian Shao (ORCID: https://orcid.org/0000-0001-7636-8483)
- Weibin Wang (ORCID: https://orcid.org/0000-0003-3087-7973)
- Yuying Yan (ORCID: https://orcid.org/0000-0001-8603-4372)
- Yibo Xie (ORCID: https://orcid.org/0009-0004-0327-2981)
- Xiangyu Zhang (ORCID: https://orcid.org/0000-0003-0170-0837)
- Tianyu Li (ORCID: https://orcid.org/0009-0005-0657-2768)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12935-025-04000-9
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Peking Union Medical College Hospital
- Peking Union Medical College