The single-cell atlas of colorectal cancer reveals cellular heterogeneity and key molecular features of the tumor immune microenvironment
This study provides a comprehensive characterization of the CRC TIME, links TIME subtypes to prognosis, and identifies SCRN1 as a potential therapeutic target, offering insights for CRC precision subtyping and immunotherapy strategies.
Authors
- Yuenan Huang (ORCID: https://orcid.org/0000-0002-5241-135X)
- JunHu Li
- Liuping You (ORCID: https://orcid.org/0000-0001-8900-6377)
- Boyu Zhang (ORCID: https://orcid.org/0000-0001-8012-9311)
- Zhiqiang Liu (ORCID: https://orcid.org/0000-0002-7684-968X)
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1007/s00262-025-04173-2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00