Age-related severity of nontuberculous mycobacterial lung disease is mediated by aberrant macrophage responses and lung microbial dysbiosis
These data reveal that nontuberculous mycobacterial pulmonary disease severity in the aged animals is driven by dysregulated inflammatory responses and dysbiosis of the lung microbiome.
Authors
- Ethan G. Napier
- Kevin L. Winthrop (ORCID: https://orcid.org/0000-0002-3892-6947)
- Eliot R. Spindel
- Luiz E. Bermudez (ORCID: https://orcid.org/0000-0003-2848-8987)
- Brianna M. Doratt (ORCID: https://orcid.org/0000-0002-8107-724X)
- Isaac R. Cinco (ORCID: https://orcid.org/0000-0003-1222-0556)
- Delphine C. Malherbe (ORCID: https://orcid.org/0000-0001-6416-6227)
- Cristina Fuss (ORCID: https://orcid.org/0000-0001-8299-0121)
- Ilhem Messaoudi (ORCID: https://orcid.org/0000-0003-3203-2405)
- Michael H. Davies
- Steven G. Kohama
- Rebecca D Geron
- Ethan V. Stuart
Institutions
- Oregon National Primate Research Center (US)
- Oregon State University (US)
- University of Kentucky (US)
- Oregon Health & Science University (US)
- Yale University (US)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.jinf.2025.106626
- Citations
- 2
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Institutes of Health
- Oregon National Primate Research Center
- Markey Cancer Center, University of Kentucky