How do I interpret transfusion transmissible infectious disease testing in a low‐risk donor population?

Here we describe how blood donor screening assays are characterized prior to use, explore possible contributors to false reactive and nonreactive results, and the importance of tracking and monitoring infectious disease positivity rates. Two case examples: one for serology and one for molecular testing demonstrate how common errors in laboratory testing can be mitigated.

Authors

Carmen L. Charlton (ORCID: https://orcid.org/0000-0002-9129-5136)
Steven J. Drews (ORCID: https://orcid.org/0000-0003-2519-1109)
Sheila F. O’Brien (ORCID: https://orcid.org/0000-0002-5332-2789)
Mark Bigham

Institutions

University of Ottawa (CA)
University of Alberta (CA)
Women and Children’s Health Research Institute (CA)
Canadian Blood Services (CA)

Publication Details

Journal: Transfusion
Published: 2025-10-09
DOI: https://doi.org/10.1111/trf.18441
Primary Topic: Hepatitis B Virus Studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

How do I interpret transfusion transmissible infectious disease testing in a low‐risk donor population?

Carmen L. Charlton, Steven J. Drews, Sheila F. O’Brien, Mark Bigham

Oct 9, 2025

Transfusion

Hepatitis B Virus Studies

article

How do I interpret transfusion transmissible infectious disease testing in a low‐risk donor population?

Carmen L. Charlton, Steven J. Drews, Sheila F. O’Brien, Mark Bigham

October 9, 2025article en

Abstract

Here we describe how blood donor screening assays are characterized prior to use, explore possible contributors to false reactive and nonreactive results, and the importance of tracking and monitoring infectious disease positivity rates. Two case examples: one for serology and one for molecular testing demonstrate how common errors in laboratory testing can be mitigated.

TransfusionVol. 65(12)

University of Ottawa (CA), University of Alberta (CA), Women and Children’s Health Research Institute (CA), Canadian Blood Services (CA)

Openalex Percentile: Top 62%

Hepatitis B Virus Studies

DOI Open Access PDF OpenAlex

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How do I interpret transfusion transmissible infectious disease testing in a low‐risk donor population? — Carmen L. Charlton, Steven J. Drews, et al. · Transfusion (2025) | TGRS Research Map | TGRS