<b>Water-insoluble exopolysaccharide synthesized by glucosyltransferases mediates the antibacterial activity of ClyR against</b> <i> <b>Streptococcus mutans</b> </i>
Water-insoluble EPS synthesized by <i>S. mutans</i> glucosyltransferases plays a critical role in modulating bacterial susceptibility to ClyR. These findings reveal a novel mechanism underlying bacteriophage lysin activity and highlight EPS as a potential target for enhancing ClyR efficacy against cariogenic biofilms.
Authors
- Tao Gong (ORCID: https://orcid.org/0000-0002-9866-9911)
- Xiaowan Wang (ORCID: https://orcid.org/0000-0001-9152-8908)
- Hang Yang (ORCID: https://orcid.org/0000-0001-6750-1465)
- Qizhao Ma (ORCID: https://orcid.org/0000-0003-4247-0134)
- Dian Zhang (ORCID: https://orcid.org/0000-0002-0979-2185)
- Yuqing Li (ORCID: https://orcid.org/0000-0002-3410-6300)
- Jiamin Chen (ORCID: https://orcid.org/0000-0003-0538-5520)
- Ziyi Yang (ORCID: https://orcid.org/0000-0002-2150-1782)
- Mai Xu
Institutions
- Chinese Academy of Sciences (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Wuhan Institute of Virology (CN)
- Stomatology Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- State Key Laboratory of Oral Diseases
Publication Details
- Journal
- Journal of Oral Microbiology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1080/20002297.2025.2566894
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00