Deciphering Alzheimer’s disease transcriptomics: exploration and validation of core genes in tau and Aβ pathological models toward novel therapeutic targets
METTL7A, SERPINB6, VASP, ENTPD2, FIBP, FUCA1, TARBP1, SORCS3, and DMXL2 may regulate the progression of AD. These findings not only deepen our mechanistic understanding of AD pathology but also provide potential candidate genes for the development of targeted therapeutic strategies against AD.
Authors
- Jin Ji (ORCID: https://orcid.org/0000-0002-2985-8372)
- Meng Xiao (ORCID: https://orcid.org/0000-0003-2103-7008)
- Hui Zhang (ORCID: https://orcid.org/0000-0002-4699-4237)
- Lu Fang (ORCID: https://orcid.org/0000-0001-6268-6173)
- Yu Cheng (ORCID: https://orcid.org/0000-0002-6658-9677)
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Xiyuan Hospital (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-10-10
- DOI
- https://doi.org/10.3389/fnagi.2025.1621153
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00