Elevated SerpinB2 regulates MUC5AC expression via STAT6 signaling in nasal epithelial cells in allergic rhinitis
SerpinB2 is upregulated in AR NECs and contributes to MUC5AC expression through STAT6 signaling pathway activation. Therefore, targeting SerpinB2 may have therapeutic value in treating AR patients.
Authors
- Qianbo Cui
- Jing Li (ORCID: https://orcid.org/0000-0002-6815-495X)
- Wei Chen (ORCID: https://orcid.org/0000-0003-4044-5058)
- Zhipeng Li (ORCID: https://orcid.org/0000-0002-6691-4070)
- Jing Wang (ORCID: https://orcid.org/0000-0002-0273-4935)
- Ying Zhu (ORCID: https://orcid.org/0009-0002-3142-284X)
Institutions
- Shanghai Sixth People's Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1669777
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China