Modulation of the lens water content changes the stiffness of the ex-vivo non-decapsulated bovine lenses
Our results demonstrate a link between lens water content and the stiffness of the nucleus of the bovine lens. This suggests that the modulation of lens water transport represents a novel strategy for the development of pharmacological interventions designed to restore accommodation in presbyopes by softening of the nucleus of the human lens.
Authors
- Paul J. Donaldson (ORCID: https://orcid.org/0000-0002-4008-1138)
- Xingzheng Pan (ORCID: https://orcid.org/0000-0003-0498-2825)
- Chen Qiu (ORCID: https://orcid.org/0009-0002-6045-2829)
- Yadi Chen (ORCID: https://orcid.org/0009-0008-1007-806X)
- Dingchang Shi
Institutions
- University of Auckland (NZ)
Publication Details
- Journal
- Frontiers in Ophthalmology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.3389/fopht.2025.1676751
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ohio State University
- Auckland Medical Research Foundation
- University of Auckland
- Health Research Council of New Zealand