A biomimetic model composed of injectable 3D muscle-like tissue, stromal and immune cells for recapitulating the rapid immune signature predictive of mRNA vaccine immunogenicity
Thus, models combining human PBMC, stromal and muscle cells could be employed for the <i>in vitro</i> validation of system vaccinology findings and non-animal vaccine pre-clinical testing.
Authors
- Cesare Gargioli (ORCID: https://orcid.org/0000-0003-1742-3969)
- Eliana M. Coccia (ORCID: https://orcid.org/0000-0002-1606-2949)
- Martina Severa (ORCID: https://orcid.org/0000-0002-0411-4545)
- Marilena P. Etna (ORCID: https://orcid.org/0000-0003-2551-393X)
- Camilla Lucca (ORCID: https://orcid.org/0000-0002-4897-9620)
- Cecília Garlanda (ORCID: https://orcid.org/0000-0002-1510-7703)
- Claudia Fuoco (ORCID: https://orcid.org/0000-0001-8372-305X)
- Alessandro Sinigaglia (ORCID: https://orcid.org/0000-0002-2386-1757)
- Anna Teresa Palamara (ORCID: https://orcid.org/0000-0001-8330-4381)
- Luisa Barzon (ORCID: https://orcid.org/0000-0003-0720-8456)
- Daniela Ricci (ORCID: https://orcid.org/0000-0002-8445-512X)
- Barbara Bottazzi
- Giada Cairo
Institutions
- University of Rome Tor Vergata (IT)
- Humanitas University (IT)
- University of Padua (IT)
- Istituto Superiore di Sanità (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1651095
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00