Analysis of risk factors for major adverse cardiac events in patients with multiple myeloma
Age, smoking, anthracycline use, and ISS stage III independently predict MACE in MM. External risk-score stratification demonstrates a clear gradient of risk but only modest discrimination, underscoring the need for prospective validation and optimization (e.g., integrating disease stage and treatment exposures). These findings support proactive cardio-oncology assessment and tailored therapy-particularly in older, smoking, ISS III, and anthracycline-treated patients.
Authors
- Tianlan Li
- Yu Feng (ORCID: https://orcid.org/0000-0003-4239-8320)
- Chunxia Mao (ORCID: https://orcid.org/0009-0009-9509-6415)
- Shuo Li (ORCID: https://orcid.org/0000-0002-0521-1662)
- Yu-Jie Xu (ORCID: https://orcid.org/0000-0001-6378-607X)
- Shi‐Lu Chen (ORCID: https://orcid.org/0000-0002-7187-9062)
- Shanshan Liu (ORCID: https://orcid.org/0000-0001-8400-8357)
- Qianqian Wang (ORCID: https://orcid.org/0009-0003-4622-0199)
- Junxia Huang (ORCID: https://orcid.org/0000-0003-4084-9159)
- Jingjing Zhou (ORCID: https://orcid.org/0000-0001-5859-9827)
- Yan Gao (ORCID: https://orcid.org/0000-0002-8363-5727)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-10-10
- DOI
- https://doi.org/10.3389/fcvm.2025.1633543
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province