Formulation and Evaluation of Organogels of Actives from Piper Betel for Treatment of Cellulitis

Topical drug delivery system of organogel of actives form of P Betel leaf oil is used to treat bacterial infection of cellulitis disease.The deeper layers of the skin and underlying tissues are affected by the common bacterial skin illness known as cellulitis.This study describes the organogel by using gelling agent soya lecithin and polymer Poloxamer 407 to obtain the drug released and drug content.Physicochemical characterization was performed for evaluation of the betel leaf oil on TLC, HPTLC and anti-oxidant activity.The formulation of organogel was evaluated for an organoleptic observation, measurement of pH, viscosity, spediability, in-vitro drug released, anti-bacterial activity, skin irritation test and stability test.Through this study, increase the drug released of organogel as increasing the concentration of gelling agent.Concentration of soya lecithin (2.5%) is then the drug released show the minimum released.Hence, gelling agent and polymer is responsible for the variation of % of drug released.