Clonal hematopoiesis of indeterminate potential as a risk factor for atrial fibrillation: Evidence of a causal relationship by Mendelian randomization study
Our findings provide genetic evidence that CHIP, particularly DNMT3a-related mutations, causally but modestly increases AF risk. There is no support for reverse causation. Elevated systolic blood pressure was identified as a significant mediator linking DNMT3a-CHIP to AF.
Authors
- Joachim Pircher (ORCID: https://orcid.org/0000-0002-8890-0884)
- Qiang Xie (ORCID: https://orcid.org/0000-0002-0974-1927)
- Wanyun Xu (ORCID: https://orcid.org/0000-0003-4787-1754)
- Wuyang Zheng (ORCID: https://orcid.org/0000-0002-8884-400X)
- Jie Li (ORCID: https://orcid.org/0000-0003-0121-1291)
- Shaofeng Zhang (ORCID: https://orcid.org/0000-0002-9920-2344)
- Yan Zhong (ORCID: https://orcid.org/0000-0001-6344-3157)
- Changqing Sun (ORCID: https://orcid.org/0000-0003-2076-1133)
- Rong Tang (ORCID: https://orcid.org/0000-0002-1645-8871)
- Guohao Wang (ORCID: https://orcid.org/0000-0002-9991-1765)
- Ling Liang (ORCID: https://orcid.org/0000-0003-3772-6262)
- Qing Zhang (ORCID: https://orcid.org/0009-0005-4472-630X)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- German Centre for Cardiovascular Research (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Heart Rhythm O2
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.hroo.2025.09.024
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00