Prospective Evaluation of the Cardiovascular Effects of BRAF and MEK Inhibitors in Patients With Melanoma
BRAF inhibitor- and MEK inhibitor-associated hypertension and CTRCD are common. The present results reinforce the utility of baseline cardiotoxicity risk stratification, including assessment of N-terminal pro-B-type natriuretic peptide. Future guidelines should consider recommending early surveillance echocardiography for higher risk patients.
Authors
- Ninian N. Lang (ORCID: https://orcid.org/0000-0001-8441-6887)
- Giles Roditi (ORCID: https://orcid.org/0000-0001-9393-7764)
- Mark C. Petrie (ORCID: https://orcid.org/0000-0002-6333-9496)
- Katriona Brooksbank (ORCID: https://orcid.org/0000-0002-9129-1717)
- Paul I. Welsh (ORCID: https://orcid.org/0000-0002-7970-3643)
- Alasdair Henderson (ORCID: https://orcid.org/0000-0002-8903-4906)
- T.R. Jeffry Evans (ORCID: https://orcid.org/0000-0002-4175-914X)
- Caroline Coats (ORCID: https://orcid.org/0000-0002-3208-470X)
- Robert J. Jones (ORCID: https://orcid.org/0000-0002-2904-6980)
- Kenneth Mangion (ORCID: https://orcid.org/0000-0002-3505-7440)
- Stephen J.H. Dobbin (ORCID: https://orcid.org/0000-0002-9111-0242)
- John McClure (ORCID: https://orcid.org/0000-0003-4839-5462)
- Claire Glen (ORCID: https://orcid.org/0000-0002-6892-1397)
- Frederick H. Epstein (ORCID: https://orcid.org/0000-0002-1954-1988)
- Peter Kellman
- Ashita Waterston (ORCID: https://orcid.org/0000-0002-2080-4749)
- Yun Yi Tan (ORCID: https://orcid.org/0000-0002-6930-2862)
- Elaine Butler
Institutions
- National Institutes of Health (US)
- Beatson West of Scotland Cancer Centre (GB)
- National Heart, Lung, and Blood Institute (US)
- Queen Elizabeth University Hospital (GB)
- University of Virginia (US)
- University of Glasgow (GB)
Publication Details
- Journal
- JACC CardioOncology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.jaccao.2025.08.006
- Citations
- 3
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 2.42