Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is upregulated in peripheral arterial disease (PAD) and a novel murine PAD model

Peripheral artery disease (PAD) is the third most common atherosclerotic bed. PAD is associated with increased risk of limb loss and death, but the mechanisms driving site-specific arterial remodeling in PAD remain unclear. This work uniquely creates a model of PAD that incorporates arterial stiffening via aging and flow disturbances and inducing atherosclerotic plaque into the murine femoral artery. By comparing murine femoral arteries with PAD arteries, piezo-type mechanosensitive ion channel component 1 (PIEZO1) was discovered as key mediator linking PAD blood flow and stiffening to untoward changes in endothelial cells, smooth muscle cells, and macrophages within femoral arteries. Targeted modulation of PIEZO1 activity provide PAD-centric therapeutic strategies and help promote the vascular health, life, and limb outcomes in patients with PAD.

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Publication Details

Journal
JVS Vascular Science
Published
2025-01-01
DOI
https://doi.org/10.1016/j.jvssci.2025.100394
Primary Topic
Erythrocyte Function and Pathophysiology
Type
article
Field-Weighted Citation Impact
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article

Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is upregulated in peripheral arterial disease (PAD) and a novel murine PAD model

Kyung In Baek, Michael Tu, Lucas H. Timmins, Maiko Sasaki et al.
JVS Vascular Science
Erythrocyte Function and Pathophysiology
article

Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is upregulated in peripheral arterial disease (PAD) and a novel murine PAD model

Kyung In Baek, Michael Tu, Lucas H. Timmins, Maiko Sasaki, Joann J. Otto, Dana M. Giangiacomo, Xiangqin Cui, Luke P. Brewster, Fujie Zhao, Rudolph L. Gleason, G. Marrero, Farbod Sedaghati, Jeffrey H. Lawson, Sandeep Kumar, Feifei Li, Hai Dong, Dennis G. Foster, Hanjoong Jo, Sandra Peprah
article en

Abstract

Peripheral artery disease (PAD) is the third most common atherosclerotic bed. PAD is associated with increased risk of limb loss and death, but the mechanisms driving site-specific arterial remodeling in PAD remain unclear. This work uniquely creates a model of PAD that incorporates arterial stiffening via aging and flow disturbances and inducing atherosclerotic plaque into the murine femoral artery. By comparing murine femoral arteries with PAD arteries, piezo-type mechanosensitive ion channel component 1 (PIEZO1) was discovered as key mediator linking PAD blood flow and stiffening to untoward changes in endothelial cells, smooth muscle cells, and macrophages within femoral arteries. Targeted modulation of PIEZO1 activity provide PAD-centric therapeutic strategies and help promote the vascular health, life, and limb outcomes in patients with PAD.

JVS Vascular ScienceVol. 6
Georgia Institute of Technology (US), Emory University (US), Duke University (US), The Wallace H. Coulter Department of Biomedical Engineering (US), Atlanta VA Health Care System (US), University of Houston (US), Texas A&M University (US)
Openalex Percentile: Top 64%
Erythrocyte Function and Pathophysiology
DOIOpen Access PDFOpenAlex
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