Ipilimumab with and without nivolumab in patients with classic Hodgkin lymphoma with progression after PD-1 blockade
• Ipilimumab achieved an ORR of 23% in patients with multiply relapsed cHL, failing to meet the primary endpoint of the trial. • Expression of immune checkpoints within the cHL microenvironment may not be sufficient to predict efficacy of targeted immunotherapies.
Authors
- Austin I. Kim (ORCID: https://orcid.org/0000-0003-1039-0658)
- Jeremy S. Abramson (ORCID: https://orcid.org/0000-0001-8467-9257)
- Justin Paul Kline (ORCID: https://orcid.org/0000-0002-2967-6448)
- Robert Allyn Redd (ORCID: https://orcid.org/0000-0002-1329-5288)
- Jennifer R. Brown (ORCID: https://orcid.org/0000-0003-2040-4961)
- Oreofe Olukemi Odejide (ORCID: https://orcid.org/0000-0002-8117-7224)
- Margaret A. Shipp (ORCID: https://orcid.org/0000-0002-3949-6897)
- Caron Alyce Jacobson (ORCID: https://orcid.org/0000-0002-0180-0654)
- Erin Michelle Parry (ORCID: https://orcid.org/0000-0002-3382-9769)
- Philippe A. Armand (ORCID: https://orcid.org/0000-0001-6098-1603)
- Inhye E. Ahn (ORCID: https://orcid.org/0000-0003-3717-287X)
- Scott J. Rodig (ORCID: https://orcid.org/0000-0003-1761-9769)
- Matthew Steven Davids (ORCID: https://orcid.org/0000-0003-4529-2003)
- Reid W. Merryman (ORCID: https://orcid.org/0000-0002-6360-3234)
- Christine E. Ryan (ORCID: https://orcid.org/0000-0003-2588-1943)
- Kathleen L. Pfaff (ORCID: https://orcid.org/0000-0003-3311-5384)
- Eric D. Jacobsen (ORCID: https://orcid.org/0000-0003-3014-0023)
- Ann Steward LaCasce (ORCID: https://orcid.org/0000-0001-7349-0176)
- Jennifer Leigh Crombie (ORCID: https://orcid.org/0000-0003-3445-5129)
- Hannah Lee (ORCID: https://orcid.org/0000-0002-1663-9170)
- David Christopher Fisher (ORCID: https://orcid.org/0000-0001-6915-8584)
- Emma J Welsh
- Mikaela M. McDonough
- Harrison Olszewski
Institutions
- Brigham and Women's Hospital (US)
- University of Chicago (US)
- Massachusetts General Hospital (US)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- Blood Neoplasia
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.bneo.2025.100173
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00