Sympathetic Overactivation Drives Colonic Eosinophil Infiltration Linked to Visceral Hypersensitivity in Irritable Bowel Syndrome
This study highlights the critical role of SNS overactivation in eotaxin-1-driven eosinophil infiltration in the colon, leading to the development of visceral hypersensitivity in IBS. The results provide important insights into the mechanistic links among increased sympathetic activity, mucosal immune alteration, and visceral hypersensitivity in individuals with IBS, suggesting potential therapeutic approaches.
Authors
- Hirosato Kanda (ORCID: https://orcid.org/0000-0001-5549-6865)
- Yilong Cui (ORCID: https://orcid.org/0000-0002-8302-1899)
- Yukiko Harima (ORCID: https://orcid.org/0009-0002-2220-2925)
- Shinichiro Shinzaki (ORCID: https://orcid.org/0000-0002-7051-618X)
- Yoshiya Ohno (ORCID: https://orcid.org/0009-0004-9190-8424)
- Yi Dai (ORCID: https://orcid.org/0000-0003-1349-9886)
- Kazunari Miyamichi (ORCID: https://orcid.org/0000-0002-7807-8436)
- Shaoqi Duan (ORCID: https://orcid.org/0000-0003-0851-3866)
- Koichi Noguchi (ORCID: https://orcid.org/0000-0001-5398-5833)
- Feng Zhu (ORCID: https://orcid.org/0009-0001-7649-8525)
- Toshiyuki Tanaka (ORCID: https://orcid.org/0000-0001-6647-3378)
- Hirokazu Fukui (ORCID: https://orcid.org/0000-0002-8642-5784)
- Taro Koike (ORCID: https://orcid.org/0000-0001-9627-6199)
- Masamichi Okubo (ORCID: https://orcid.org/0000-0001-8097-4304)
Institutions
- Kansai Medical University (JP)
- Hyogo Medical University (JP)
- Kobe Medical Center (JP)
- RIKEN Center for Biosystems Dynamics Research (JP)
- Kobe University (JP)
- Hyogo University (JP)
- Kobe College (JP)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101658
- Citations
- 1
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 2.01