Aminoguanidine attenuates arsenic-induced hepatic oxidative stress: Dose-dependent effects in a mouse model
Aminoguanidine demonstrates dose-dependent hepatoprotective effects against arsenic-induced oxidative damage, with 50 mg/kg/day showing optimal efficacy. Further investigation of lower doses over extended periods is warranted to establish its therapeutic potential in arsenic toxicity.
Authors
- Jafar Ahmadi (ORCID: https://orcid.org/0000-0002-2426-2019)
- Somayyeh Karami‐Mohajeri (ORCID: https://orcid.org/0000-0001-6256-6550)
- Matin Baghani (ORCID: https://orcid.org/0000-0003-3569-5714)
- Mahshid Jamshidi
- Milad Rahimzadegan (ORCID: https://orcid.org/0000-0001-7706-2726)
- Behnam Ghorbani-Nejad
- Nastaran Allahdini Hasaruyieh
- Leila Poudineh
Institutions
- Kerman University of Medical Sciences (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Toxicology Reports
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.toxrep.2025.102136
- Primary Topic
- Arsenic contamination and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00