Pathogenic OTUD3 Mutations Predispose to Ulcerative Colitis Due to Barrier Dysfunction
Our results demonstrate that OTUD3 is required for colonic epithelial barrier function, and plays a role in the pathogenesis of UC.
Authors
- John D. Hooper (ORCID: https://orcid.org/0000-0003-1054-8486)
- Timothy H. Florin (ORCID: https://orcid.org/0000-0003-1866-9848)
- Sumaira Z. Hasnain (ORCID: https://orcid.org/0000-0001-8577-8628)
- Tashbib Khan (ORCID: https://orcid.org/0000-0001-5203-0672)
- Rohan Lourie (ORCID: https://orcid.org/0000-0002-0093-911X)
- Adam D. Ewing (ORCID: https://orcid.org/0000-0002-4544-994X)
- Rachid Zagani
- Robert J. Gordon (ORCID: https://orcid.org/0009-0008-7071-6545)
- Rabina Giri (ORCID: https://orcid.org/0000-0002-6712-6076)
- Thomas Kryza (ORCID: https://orcid.org/0000-0003-1668-8551)
- Andrew C. Perkins (ORCID: https://orcid.org/0000-0003-3644-7093)
- Ranjeny Thomas (ORCID: https://orcid.org/0000-0002-0518-8386)
- Anne‐Sophie Bergot (ORCID: https://orcid.org/0000-0003-2658-4449)
- Jakob Begun (ORCID: https://orcid.org/0000-0001-5256-7672)
- Minyi Lee (ORCID: https://orcid.org/0000-0003-3814-9890)
- Graham Magor
- Manish Gala (ORCID: https://orcid.org/0000-0002-3126-0783)
- Veronika Schreiber (ORCID: https://orcid.org/0000-0001-6088-7828)
- Yaowu He (ORCID: https://orcid.org/0000-0002-7828-263X)
Institutions
- Translational Research Institute (AU)
- Mater Health Services (AU)
- The University of Queensland (AU)
- Massachusetts General Hospital (US)
- Tweed Shire Council (AU)
- Mater Research (AU)
- Australian Centre for HIV and Hepatitis Virology Research (AU)
- Mater Hospital (GB)
- Mater Adult Hospital (AU)
- Monash University (AU)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101659
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00