Pathogenic OTUD3 Mutations Predispose to Ulcerative Colitis Due to Barrier Dysfunction

Our results demonstrate that OTUD3 is required for colonic epithelial barrier function, and plays a role in the pathogenesis of UC.

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Publication Details

Journal
Cellular and Molecular Gastroenterology and Hepatology
Published
2025-10-10
DOI
https://doi.org/10.1016/j.jcmgh.2025.101659
Primary Topic
Inflammatory Bowel Disease
Type
article
Field-Weighted Citation Impact
0.00
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article

Pathogenic OTUD3 Mutations Predispose to Ulcerative Colitis Due to Barrier Dysfunction

John D. Hooper, Timothy H. Florin, Sumaira Z. Hasnain, Tashbib Khan et al.
Cellular and Molecular Gastroenterology and Hepatology
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Pathogenic OTUD3 Mutations Predispose to Ulcerative Colitis Due to Barrier Dysfunction

John D. Hooper, Timothy H. Florin, Sumaira Z. Hasnain, Tashbib Khan, Rohan Lourie, Adam D. Ewing, Rachid Zagani, Robert J. Gordon, Rabina Giri, Thomas Kryza, Andrew C. Perkins, Ranjeny Thomas, Anne‐Sophie Bergot, Jakob Begun, Minyi Lee, Graham Magor, Manish Gala, Veronika Schreiber, Yaowu He
article en

Abstract

Our results demonstrate that OTUD3 is required for colonic epithelial barrier function, and plays a role in the pathogenesis of UC.

Cellular and Molecular Gastroenterology and HepatologyVol. 20(2)
Translational Research Institute (AU), Mater Health Services (AU), The University of Queensland (AU), Massachusetts General Hospital (US), Tweed Shire Council (AU), Mater Research (AU), Australian Centre for HIV and Hepatitis Virology Research (AU), Mater Hospital (GB), Mater Adult Hospital (AU), Monash University (AU)
Openalex Percentile: Top 69%
Inflammatory Bowel Disease
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