Synthesis, characterizacion and study of novel heterobimetallic RAPTA-type Ru(II) complexes

The new monometallic RAPTA complex [RuCl2(η6-p-cym)(dmPTA-κP)](CF3SO3)2 (1) and novel heterobimetallic complexes [RuCl2(η6-p-cym)-μ-(dmoPTA)-(1κP:2κ2N,N′-M(L)Cl2)] (M = Cu (3); M = Cu, L = DMF (3·3DMF); M = Pd (4)) have been synthesized and characterized (dmPTA = N,N′-dimethyl-1,3,5-triaza-7-phosphaadamantane; dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane). The synthesized complexes have been fully characterized by elemental analysis and spectroscopic techniques. The crystal structure of the complexes 2, 3·3DMF and 4 were determined by single-crystal X-ray diffraction. The stability of complexes was studied in water and DMSO at room temperature and 37 °C. The anticancer activity against intestinal Caco-2/TC7 cells was studied.