Investigating the Neuroprotective Effects of Curcumin in Scopolamine-induced Animal Model of Dementia: A Synergistic Approach to Mitigate Cognitive Decline

INTRODUCTION Millions of people worldwide live with dementia, a complex neurodegenerative disease characterized by cognitive decline and imposing a heavy burden on public health systems. 60-80% of patients suffering from dementia are diagnosed with Alzheimer's disease (AD) making it most common type of dementia disorders [1-3]. Despite progress in understanding its pathogenesis, new neuroprotective drugs still need to be investigated due to ineffective/failure of treatment in some cases [4]. Curcumin has attracted attention for its therapeutic benefits in neurodegenerative diseases due to its anti-amyloidogenic, anti-inflammatory and antioxidant properties [5]. Curcumin shows promise as a modifier of cognitive decline through multiple mechanisms.