Which ‘dose rate’ definition describes the FLASH sparing effect for scanned proton beams? A meta-analysis of skin murine data
We compiled preclinical proton PBS skin toxicity data to assess how various dose rate definitions (field, average, and dose average) explain the FLASH sparing effect. Only average dose rate (ADR), accounting for 'effective irradiation time,' reliably describes it. We identified high-dose and ADR regions where the effect was consistently observed.
Authors
- Isabella Colizzi (ORCID: https://orcid.org/0009-0007-5519-3670)
- David Meer
- B. Sørensen
- P.R. Poulsen (ORCID: https://orcid.org/0000-0001-9940-7609)
- S. Psoroulas (ORCID: https://orcid.org/0000-0001-7576-3238)
- Antony Lomax (ORCID: https://orcid.org/0000-0002-0666-425X)
Institutions
- Paul Scherrer Institute (CH)
- Aarhus University Hospital (DK)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.radonc.2025.111206
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Research Centre
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Novo Nordisk Fonden
- Siemens Healthineers