Preoperative plasma short- and branched-chain fatty acids in relation to risk of complications after colorectal cancer surgery: a prospective cohort study
Our findings suggest that microbial fermentation processes, mainly those resulting in higher SCFA levels, may be linked to postoperative recovery. These findings provide leads for future studies investigating the role of preoperative diet, especially the balance between fiber and protein intake, and microbial metabolism in relation to postoperative recovery of patients with CRC. This study was registered at clinicaltrials.gov with registration number NCT03191110.
Authors
- Flip M. Kruyt
- Renate M. Winkels (ORCID: https://orcid.org/0000-0002-0376-8811)
- Ellen Kampman (ORCID: https://orcid.org/0000-0002-8606-7075)
- N. Tjarda van Heek
- Adrian McCann (ORCID: https://orcid.org/0000-0002-5728-5321)
- Dieuwertje E. Kok (ORCID: https://orcid.org/0000-0001-7154-8207)
- Arve Ulvik (ORCID: https://orcid.org/0000-0003-1574-9690)
- Per Magne Ueland (ORCID: https://orcid.org/0000-0002-1903-0571)
- Edoardo Capuano (ORCID: https://orcid.org/0000-0003-4705-8210)
- Erwin G. Zoetendal (ORCID: https://orcid.org/0000-0002-7149-0727)
- Johannes H.W. de Wilt (ORCID: https://orcid.org/0000-0001-6773-9668)
- Niels Klaassen‐Dekker
- Fränzel J.B. van Duijnhoven
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Ziekenhuis Gelderse Vallei (NL)
- Bevital (Norway) (NO)
- Wageningen University & Research (NL)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.ajcnut.2025.10.001
- Primary Topic
- Enhanced Recovery After Surgery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- World Cancer Research Fund International
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Wereld Kanker Onderzoek Fonds
- World Cancer Research Fund
- Wageningen University and Research