Multipotent adult progenitor cell therapy: Effect of timing and frequency on lung health in preterm lambs during inflammation
All three MAPC regimens improve preterm lung outcomes under inflammatory conditions. However, mechanisms underlying stem cell therapy are modulated in a time- and insult-dependent manner, highlighting the potential of stem cell therapy as personalized approach.
Authors
- Tim Brokken (ORCID: https://orcid.org/0009-0008-4010-5356)
- Luc J. I. Zimmermann (ORCID: https://orcid.org/0000-0002-1409-3821)
- Daan R. M. G. Ophelders (ORCID: https://orcid.org/0000-0001-7410-5102)
- Helene Widowski
- Shahab Jolani (ORCID: https://orcid.org/0000-0002-8508-0702)
- Matthias Christian Hütten (ORCID: https://orcid.org/0000-0003-4870-5782)
- Ilse H. de Lange (ORCID: https://orcid.org/0000-0002-7780-9399)
- Mireille M.J.P.E. Sthijns (ORCID: https://orcid.org/0000-0003-1746-8171)
- C. Severens‐Rijvers
- Vanessa L.S. LaPointe (ORCID: https://orcid.org/0000-0002-0887-7443)
- Charlotte van Gorp (ORCID: https://orcid.org/0000-0003-2920-9783)
- Niki L. Reynaert (ORCID: https://orcid.org/0000-0002-8577-8094)
- Christof Seiler (ORCID: https://orcid.org/0000-0001-8802-3642)
- J. Jane Pillow (ORCID: https://orcid.org/0000-0002-6500-0138)
- Tim G. A. M. Wolfs (ORCID: https://orcid.org/0000-0003-4417-4144)
- Tammo Delhaas (ORCID: https://orcid.org/0000-0001-6897-9700)
- Sophie M. L. Neuen (ORCID: https://orcid.org/0009-0003-2526-079X)
- Peter G. J. Nikkels (ORCID: https://orcid.org/0000-0002-7279-4589)
Institutions
- The University of Western Australia (AU)
- Maastricht University Medical Centre (NL)
- United Nations University – Maastricht Economic and Social Research Institute on Innovation and Technology (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Department of Health (TW)
Publication Details
- Journal
- Pharmacological Research
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.phrs.2025.107979
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00