Alterations in the transcriptome of human primary bronchial epithelial cells exposed to emissions from a heated tobacco product
Despite significant inter-donor variability, IQOSE induced specific gene signatures associated with pathways known to be involved in (smoking-related) lung diseases in all donors. Collectively, these findings provide novel insights into the molecular toxicity of IQOS mainstream emissions in human bronchial epithelial cells.
Authors
- Marcel H. M. van Herwijnen
- R Talhout
- M Davigo (ORCID: https://orcid.org/0000-0002-8202-1408)
- Antoon Opperhuizen
- Marcha Verheijen (ORCID: https://orcid.org/0000-0002-2684-838X)
- Frederik‐Jan van Schooten (ORCID: https://orcid.org/0000-0001-8111-8198)
- A G R Mommers
- F. Caiment
- A.H.V. Remels
Institutions
- Maastricht University (NL)
- National Institute for Public Health and the Environment (NL)
- Netherlands Food and Consumer Product Safety Authority (NL)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.bbagen.2025.130869
- Primary Topic
- Energy and Environment Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00