The fat-mass and obesity-associated gene rs9939609 T allele is prominent among the native Mexican population and is associated with risk for Type 2 diabetes and metabolic dysfunction-associated steatotic liver disease
The <i>FTO</i> T allele was prominent among native Mexicans. In contrast, the A allele prevailed among the Mestizo with higher European ancestry. The TT genotype carriers had higher odds of IR, HTG, and HGL, highlighting the genetic predisposition to T2D and MASLD in populations exposed to obesogenic and hepatopathogenic environments.
Authors
- Sonia Román (ORCID: https://orcid.org/0000-0001-7061-6634)
- Claudia Ojeda‐Granados (ORCID: https://orcid.org/0000-0001-9734-558X)
- Arturo Panduro (ORCID: https://orcid.org/0000-0003-4784-748X)
- Leonardo Leal-Mercado
- Maricruz Sepúlveda-Villegas (ORCID: https://orcid.org/0000-0002-8023-5533)
- Juan Pablo Cardenas-Benitez
Institutions
- Universidad de Guadalajara (MX)
- Hospital Civil de Guadalajara (MX)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-10-10
- DOI
- https://doi.org/10.3389/fnut.2025.1569342
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Universidad de Guadalajara