Psychometric properties of the Vitiligo Noticeability Scale using data from a phase II randomized study of upadacitinib in adults with nonsegmental vitiligo
The Vitiligo Noticeability Scale (VNS) is a patient-reported outcome that assesses treatment success. It was originally validated by measuring the cosmetic acceptability of a single target patch before and after treatment. We further investigated the psychometric properties of the VNS and determined if it could be used as a global measure of vitiligo noticeability by using in-trial data from a phase II randomized trial (NCT04927975) assessing upadacitinib, an oral selective Janus kinase inhibitor, in patients with nonsegmental vitiligo. We found the VNS to be a valid and reliable global measure that can differentiate between clinically distinct groups and is sensitive to change.
Authors
- Jung Min Bae (ORCID: https://orcid.org/0000-0001-5975-8519)
- Heidi S. Camp (ORCID: https://orcid.org/0009-0003-2632-015X)
- Rohini Sen (ORCID: https://orcid.org/0000-0002-8782-2474)
- Iltefat Hamzavi (ORCID: https://orcid.org/0000-0002-3137-5601)
- Karin S. Coyne (ORCID: https://orcid.org/0000-0002-5773-131X)
- Bethanee J. Schlosser (ORCID: https://orcid.org/0000-0003-4785-0670)
- Khaled Ezzedine (ORCID: https://orcid.org/0000-0002-5468-4589)
- Robin Pokrzywinski (ORCID: https://orcid.org/0000-0002-1781-8197)
- Ahmed M. Soliman (ORCID: https://orcid.org/0009-0008-8632-1396)
- Mary Kate Ladd
Institutions
- University of North Carolina Wilmington (US)
- Henry Ford Health System (US)
- Université Paris-Est Créteil (FR)
- AbbVie (United States) (US)
- The Catholic University of Korea St. Vincent's Hospital (KR)
- Hôpitaux Universitaires Henri-Mondor (FR)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1093/bjd/ljaf391
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 0.00