Utility of cytomegalovirus (CMV) qualitative polymerase chain reaction from gastrointestinal biopsies in diagnosis of CMV gastrointestinal disease: A 10-year retrospective study
CMV tissue PCR correctly identified CMV GI disease in 100 % of histology-proven cases. Specificity was poor, likely reflecting detection of viral shedding. Overall, our study suggests that CMV tissue PCR should be reserved to rule out CMV GI disease in high pre-test probability settings (e.g. patients with known risk factors and compatible symptoms).
Authors
- Christopher F. Lowe (ORCID: https://orcid.org/0000-0001-9320-4499)
- Nancy Matic (ORCID: https://orcid.org/0000-0002-4158-6955)
- Calvin Ka-Fung Lo (ORCID: https://orcid.org/0000-0003-3664-736X)
- Cole Schonhofer (ORCID: https://orcid.org/0000-0002-5226-5137)
- Daniel R Owen (ORCID: https://orcid.org/0000-0002-1386-9624)
- Alissa Wright
- Sara Belga (ORCID: https://orcid.org/0000-0003-1725-1407)
- David F. Schaeffer (ORCID: https://orcid.org/0000-0002-7341-1308)
- Khuloud Aldhaheri
Institutions
- Providence Health Care (CA)
- University of British Columbia (CA)
- United Arab Emirates University (AE)
- Vancouver General Hospital (CA)
- St. Paul's Hospital (CA)
Publication Details
- Journal
- Journal of Clinical Virology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.jcv.2025.105879
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00