Small extracellular vesicles produced from canine adipose-derived mesenchymal stem cells mitigate diabetes mellitus in streptozotocin-induced mice via β-cell revitalization
sEVs exhibit robust revitalizing, metabolic, and immunomodulatory properties, effectively mitigating diabetes-related dysfunctions in vitro and in vivo. These findings highlight sEVs as a novel regenerative therapy for diabetes and its complications, providing a strong foundation for future clinical translation.
Authors
- Chenphop Sawangmake (ORCID: https://orcid.org/0000-0003-2619-9487)
- Parkpoom Siriarchavatana (ORCID: https://orcid.org/0000-0002-1104-8566)
- Poorichaya Somparn (ORCID: https://orcid.org/0000-0002-7422-1135)
- Daneeya Na Nan (ORCID: https://orcid.org/0000-0001-9382-4073)
- Watchareewan Rodprasert (ORCID: https://orcid.org/0000-0002-6134-1461)
- Saranyou Oontawee (ORCID: https://orcid.org/0000-0001-6406-4124)
- Thanaphum Noom Osathanon (ORCID: https://orcid.org/0000-0003-1649-6357)
- Teerawut Nedumpun (ORCID: https://orcid.org/0000-0002-9924-1036)
- Sayamon Srisuwatanasagul (ORCID: https://orcid.org/0000-0002-9875-7495)
- Hiroshi Egusa (ORCID: https://orcid.org/0000-0002-0200-8132)
- Anatcha Thongsit
Institutions
- Chulalongkorn University (TH)
- Kanchanaburi Rajabhat University (TH)
- Tohoku University (JP)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12917-025-05042-x
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00