Volume histogram analysis of whole-lung CT: differentiating usual from nonspecific interstitial pneumonias and predicting prognosis
The VHA model could effectively differentiate radiological UIP patterns and may help predict the prognosis of patients with interstitial pneumonia. A formula-based model using CT volume histogram analysis (VHA) of each lung lobe was developed to differentiate usual interstitial pneumonia (UIP) from nonspecific interstitial pneumonia (NSIP). The VHA model demonstrated strong diagnostic performance, achieving an area under the curve of 0.81 in external validation, and also statistically correlated with patient prognosis.
Authors
- Yoshikazu Inoue (ORCID: https://orcid.org/0000-0003-3994-874X)
- Yoshiaki Zaizen (ORCID: https://orcid.org/0000-0003-2274-4599)
- Shigeki Shimizu (ORCID: https://orcid.org/0000-0001-9675-2589)
- Shuichi Tanoue (ORCID: https://orcid.org/0000-0001-8813-8108)
- Takeshi Johkoh
- Kenta Murotani (ORCID: https://orcid.org/0000-0003-0623-9365)
- Toru Arai (ORCID: https://orcid.org/0000-0002-2222-0683)
- Tomonori Chikasue (ORCID: https://orcid.org/0000-0001-6519-3446)
- Kiminori Fujimoto (ORCID: https://orcid.org/0000-0001-8681-7588)
- Masaki Tominaga (ORCID: https://orcid.org/0000-0002-6972-1338)
- Akiko Sumi (ORCID: https://orcid.org/0000-0002-4830-4033)
- Hiromitsu Sumikawa
- Masaki Okamoto (ORCID: https://orcid.org/0000-0002-9298-3504)
- Kotaro Matsumoto
Institutions
- Kurume University (JP)
- Kyushu University (JP)
- National Kyushu Medical Center (JP)
- Kurume University Medical Center (JP)
- Kansai Rosai Hospital (JP)
- Fukujuji Hospital (JP)
- NHO Kinki Chuo Chest Medical Center (JP)
Publication Details
- Journal
- Japanese Journal of Radiology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1007/s11604-025-01880-9
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Health, Labour and Welfare
- Japanese Respiratory Society