Generation of two isogenic induced pluripotent stem cell lines derived from a Hispanic individual with Alzheimer’s Disease and mosaic for loss of the Y chromosome
Mosaic loss of the Y chromosome (LOY) is a somatic phenomenon that occurs in males as they age (Jacobs, 1963; Forsberg, 2017; Danielsson, 2020) and is associated with an elevated risk of developing numerous diseases, including Alzheimer's Disease (AD) (Dumanski, 2016; Palmer, et al., 2022; Garcia-Gonzalez, 2023), cancer (Holmes, 1985; Loftfield, 2018), diabetes (Loftfield, 2018), age related macular degeneration (Grassmann, 2019), and autoimmune disease (Persani, 2012; Lleo, 2013). The induced pluripotent cell lines (iPSCs) UMi050-A and UMi050-B were derived from a Hispanic male with loss of the Y chromosome in his blood and diagnosed with AD. This isogenic pair of lines with and without a Y chromosome is a unique resource to delve into the mechanism of LOY and its relationship to AD risk.
Authors
- Eugene Tang (ORCID: https://orcid.org/0000-0001-5192-2521)
- Jonathan L. Haines (ORCID: https://orcid.org/0000-0002-4351-4728)
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Holly N. Cukier (ORCID: https://orcid.org/0000-0003-3459-7792)
- Brooke A. DeRosa (ORCID: https://orcid.org/0000-0002-7878-9799)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Margaret A. Pericak‐Vance (ORCID: https://orcid.org/0000-0001-7283-8804)
- Yeunjoo E. Song (ORCID: https://orcid.org/0000-0002-7452-3731)
- Esther Gu
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Lauren Coombs
- Anna Rosa Lazzaro
- Denise R Leyva
Institutions
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.scr.2025.103851
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00