Generation of an induced pluripotent stem cell line from a patient with Varicose veins
Chronic venous disease is among the most common vascular diseases globally. Varicose veins (VV), characterized by permanent dilation, elongation, and tortuosity of superficial veins, is a manifestation of chronic venous disease. Here, we generated an induced pluripotent stem cell (iPSC) line from PBMCs obtained from a patient with VV. The iPSC line exhibited typical morphology, maintained undifferentiated hPSC state markers, demonstrated a normal karyotype, and successfully differentiated into all three germ layers. This iPSC line provides a valuable platform to model VV pathogenesis and investigate the molecular mechanisms underlying venous dysfunction.
Authors
- Amit Manhas (ORCID: https://orcid.org/0000-0001-6044-4576)
- Nazish Sayed (ORCID: https://orcid.org/0000-0002-8229-721X)
- Chikage Noishiki (ORCID: https://orcid.org/0000-0002-4623-1176)
- Shaunak Adkar (ORCID: https://orcid.org/0000-0002-8893-2413)
- Nicholas J. Leeper (ORCID: https://orcid.org/0000-0002-0905-2806)
- Karim Sallam (ORCID: https://orcid.org/0000-0003-3469-6571)
- Eri Fukaya (ORCID: https://orcid.org/0000-0001-8328-5133)
- Lu Liu (ORCID: https://orcid.org/0000-0001-8023-7187)
- David Wu
- Said Hamid Sadat (ORCID: https://orcid.org/0009-0006-7885-6214)
- Dipti Tripathi (ORCID: https://orcid.org/0000-0001-7296-6654)
Institutions
- Cardiovascular Institute of the South (US)
- The Family Center (US)
- Stanford Medicine (US)
- Center for Vascular Biology Research (US)
- Stanford University (US)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1016/j.scr.2025.103850
- Primary Topic
- Diagnosis and Treatment of Venous Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00