Performance of the low-cost phenotypic thin-layer agar MDR/XDR-TB Colour Test (first generation, 1G, Color Plate Test) for identifying drug-resistant Mycobacterium tuberculosis isolates in a resource-limited setting
The accuracy of Mtb drug-susceptibility testing was similar comparing: Colour Test versus IPM, Colour Test versus MGIT; and comparing IPM versus MGIT. The Colour Test was easy to use and determined drug-susceptibility significantly more rapidly than the IPM and MGIT assays. Thus, implementing the Colour Test in clinical settings could make drug-susceptibility testing more accessible and rapid in high TB burden, and resource-constrained settings, including in Ethiopia.
Authors
- Juan Ignacio García (ORCID: https://orcid.org/0000-0001-8263-3140)
- Sebsib Neway (ORCID: https://orcid.org/0000-0002-2033-5874)
- Abay Atnafu (ORCID: https://orcid.org/0000-0001-7594-4004)
- Kelemework Adane (ORCID: https://orcid.org/0000-0002-0409-5620)
- Jonathan Gelfond (ORCID: https://orcid.org/0000-0002-0773-3683)
- Jordi Bertran Torrelles (ORCID: https://orcid.org/0000-0001-7702-5941)
- Melaku Tilahun (ORCID: https://orcid.org/0000-0002-3101-3926)
- Binyam Mebrat (ORCID: https://orcid.org/0000-0003-4518-4395)
- Amberlee Hicks
- Liya Wassie (ORCID: https://orcid.org/0000-0002-5494-5275)
- Carlton A. Evans (ORCID: https://orcid.org/0000-0002-6873-5447)
- Shuhua Wang
- Yimtubezenash Woldeamanuel
- Lelisa Oluma
Institutions
- Texas Biomedical Research Institute (US)
- The University of Texas at San Antonio Health Science Center (US)
- Universidad Peruana Cayetano Heredia (PE)
- The Ohio State University Wexner Medical Center (US)
- Prisma (PE)
- Biomedical Research Institute (US)
- Armauer Hansen Research Institute (ET)
- International Biomedical (United States) (US)
- Addis Ababa University (ET)
- Imperial College London (GB)
- The Ohio State University (US)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1186/s12866-025-04347-z
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00