A chimeric enediyne for targeted degradation of a tumor-associated protein
A protein-radical-oxidation targeting enediyne chimera (PROTEC) comprising an enediyne warhead and a protein-targeting moiety was developed for the selective degradation of a tumor-associated protein. PROTEC operates by forming a binary complex with the protein of interest and inducing oxidative protein degradation by the radical species generated from the cycloaromatization of the enediyne moiety.
Authors
- Jiaming Lan (ORCID: https://orcid.org/0009-0007-1242-9866)
- Aiguo Hu (ORCID: https://orcid.org/0000-0003-0456-7269)
- Xuejie Li (ORCID: https://orcid.org/0009-0001-3074-2940)
- Haonan Cheng (ORCID: https://orcid.org/0000-0002-8321-0841)
- Fangxu Pu
Institutions
- East China University of Science and Technology (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Nutrition and Health (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01344e
- Citations
- 2
- Primary Topic
- Cyclization and Aryne Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.87