Pro-inflammation and clinical correlates of unsuppressed HIV-viral load in children living with perinatally-acquired HIV 1 in Zambia
One in six children with perinatally acquired HIV in Ndola, Zambia, had unsuppressed viral load, which was associated with poor ART adherence and lower CD4 counts. Proinflammatory markers, TNF-α and D-dimer, showed no significant differences between suppressed and unsuppressed groups, suggesting they may not be reliable indicators of viral control. Enhanced adherence support and further research on immune dysregulation are needed.
Authors
- Sepiso K. Masenga (ORCID: https://orcid.org/0000-0003-4376-5831)
- Benson M. Hamooya (ORCID: https://orcid.org/0000-0003-1385-0998)
- Kingsley Kamvuma (ORCID: https://orcid.org/0000-0001-7311-5122)
- Lweendo Muchaili (ORCID: https://orcid.org/0000-0002-2808-0319)
- Situmbeko Liweleya (ORCID: https://orcid.org/0009-0008-8698-5272)
- Sydney Mulamfu
- John Nzobokela (ORCID: https://orcid.org/0009-0009-9687-2113)
Institutions
- Livingstone College (US)
- Livingstone Hospital (ZA)
- Mulungushi University (ZM)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1371/journal.pone.0334109
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00