Detection of Prostate Cancer Metastases During Pelvic Lymph Node Dissection with the PSMA-Targeted Fluorescent Agent OTL78: A Phase II Study
Intraoperative fluorescence imaging with the tracer OTL78 is a feasible technique for identifying metastatic lymph nodes during PLND. Fluorescence guidance may assist in detecting small metastatic deposits within nodal clusters that are otherwise difficult to localize. Larger studies are needed to validate these findings and optimize the imaging protocol for broader clinical use.
Authors
- Judith A. Stibbe (ORCID: https://orcid.org/0000-0003-2955-486X)
- Daan G. J. Linders (ORCID: https://orcid.org/0000-0003-4524-4175)
- Robin A. Faber
- Stijn Crobach
- Shadhvi S. Bhairosingh
- Rob F. M. Bevers
- Erik J. van Gennep (ORCID: https://orcid.org/0000-0001-5471-5499)
- Timothy G. Biro
- Prof Alexander L. Vahrmeijer
- Prof Jacobus Burggraaf
Institutions
- Leiden University Medical Center (NL)
- Noordwest Ziekenhuisgroep (NL)
- On Target Laboratories (United States) (US)
- Centre for Human Drug Research (NL)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1007/s11307-025-02052-x
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universiteit Leiden
- Leids Universitair Medisch Centrum