Personalised screening intensity based on existing lung cancer risk and spirometry
Baseline risk could be used to extend intervals for substantial numbers of lower-risk participants, thereby reducing cost and screening harms, while focusing resources on those at highest risk to avoid delayed detection. Adding FEV<sub>1</sub> % pred is unlikely to meaningfully contribute to next-round risk prediction.
Authors
- Matthew Sperrin (ORCID: https://orcid.org/0000-0002-5351-9960)
- Patrick Goodley (ORCID: https://orcid.org/0000-0002-5729-2548)
- Richard Booton (ORCID: https://orcid.org/0000-0003-4512-2899)
- Zoe Merchant (ORCID: https://orcid.org/0000-0001-6217-2973)
- Haval Balata (ORCID: https://orcid.org/0000-0002-8596-9376)
- Anna Sharman
- Hilary A. Robbins (ORCID: https://orcid.org/0000-0001-6041-6866)
- Hana Zahed (ORCID: https://orcid.org/0000-0002-5731-8859)
- Philip Crosbie (ORCID: https://orcid.org/0000-0001-8941-4813)
- Kath Hewitt
- Alberto Valdés Alonso (ORCID: https://orcid.org/0000-0002-8178-0314)
Institutions
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
- Centre international de recherche sur le cancer (FR)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1183/23120541.00974-2025
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- World Health Organization
- American College of Radiology Imaging Network
- Centre International de Recherche sur le Cancer
- ECOG-ACRIN Cancer Research Group
- University of Manchester
- National Institutes of Health
- National Cancer Institute