FNA biopsy of breast specimens effectively harvests cells for patient‐derived organoids modeling ductal carcinoma in situ
FNAB effectively obtains cells for PDOs modeling DCIS. CNB yielded PDOs with a high success rate, but they were slow to establish. The time to organoid growth was significantly shorter for FNAB specimens. Thus, FNAB offers an efficient alternative for breast PDO culture and can reduce the time and resources spent on generating PDO cultures.
Authors
- Mark M. Moasser (ORCID: https://orcid.org/0000-0003-4411-4336)
- Shruti Warhadpande
- Jasmine Wong (ORCID: https://orcid.org/0000-0001-6440-0431)
- Michael Alvarado (ORCID: https://orcid.org/0009-0003-7309-567X)
- Nadine Goldhammer (ORCID: https://orcid.org/0000-0003-1644-3984)
- George C. de Castro
- Rita A. Mukhtar (ORCID: https://orcid.org/0000-0001-8079-7846)
- Poonam Vohra (ORCID: https://orcid.org/0000-0002-6055-4465)
- Cristian K. Maldonado Rodas (ORCID: https://orcid.org/0000-0003-0096-9316)
- Laura J. Esserman (ORCID: https://orcid.org/0000-0001-9202-4568)
- Ronald Balassanian (ORCID: https://orcid.org/0000-0001-5756-9052)
- Kirithiga Ramalingam (ORCID: https://orcid.org/0000-0002-1774-6891)
- Karen Goodwin (ORCID: https://orcid.org/0000-0002-8376-3809)
- Cheryl Ewing
- Shoko Abe (ORCID: https://orcid.org/0000-0001-9457-2779)
Institutions
- University of California, San Francisco (US)
- Chan Zuckerberg Initiative (United States) (US)
Publication Details
- Journal
- Cancer Cytopathology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1002/cncy.70052
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Institutes of Health
- University of California, San Francisco