ITPR1 autoantibody-associated autoimmunity as a cause of newly emerging cognitive decline mimicking Alzheimer's disease: Case report and brief review of the literature
This case underscores the clinical importance of CSF analysis and testing for anti-neural autoantibodies, including less common reactivities, in case of rapid cognitive decline even in patients with known or suspected neurodegenerative disease, such as AD, with ITPR1 representing a novel autoimmune target antigen.
Authors
- Brigitte Wildemann (ORCID: https://orcid.org/0000-0002-5389-3338)
- Nicolas Kunath (ORCID: https://orcid.org/0000-0002-7641-511X)
- Lars Komorowski (ORCID: https://orcid.org/0000-0003-4698-3316)
- Gøril Rolfseng Grøntvedt (ORCID: https://orcid.org/0000-0003-2057-6683)
- Irina I. Serysheva (ORCID: https://orcid.org/0000-0001-6266-3422)
- Sven Jarius (ORCID: https://orcid.org/0000-0003-4849-2545)
- Hermod Arne Bollandsås Ramfjord
- Elisabeth Volden Kvisvik
- Marton Konyves-Kolonics
Institutions
- Norwegian University of Science and Technology (NO)
- Heidelberg University (DE)
- St Olav's University Hospital (NO)
- Euroimmun Medizinische Labordiagnostika (Germany) (DE)
- Imaging Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Journal of Neuroimmunology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1016/j.jneuroim.2025.578774
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00