Increased pre-alpha functional connectivity in dementia with Lewy bodies
BackgroundResting-state EEG studies have shown that neurodegenerative dementias like Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) can alter cortical functional connectivity. In DLB, the presence of a pre-alpha rhythm suggests frequency-specific network dysfunctions that remain poorly understood.ObjectiveIn the present study we tested the hypothesis that electroencephalography (EEG) recordings in DLB patients may show abnormal cortical functional connectivity.MethodsResting-state EEG activity was recorded in 73 DLB, 70 AD, and 41 healthy control (HC) participants from seven European DLB Consortium Centers. We used eLORETA to calculate lagged linear connectivity (LLC) from EEG sources at delta, theta, pre-alpha, alpha, beta, gamma bands.ResultsStatistical analyses revealed greater fronto-occipital connectivity at the theta and pre-alpha bands in the DLB group compared to the AD and HC groups. Furthermore, the DLB and AD groups displayed reduced alpha LLC compared to the HC group.ConclusionsThe results suggest that in DLB patients, resting-state EEG pre-alpha activity is not a local process. Instead, it may reflect enhanced functional connectivity, possibly propagating dysfunctional thalamocortical connectivity, within long fronto-occipital tracts.
Authors
- Rocco Palumbo (ORCID: https://orcid.org/0000-0002-2385-5840)
- Irena Rektorová (ORCID: https://orcid.org/0000-0002-5455-4573)
- Simona Luzzi (ORCID: https://orcid.org/0000-0003-3802-2320)
- Michèle Tinazzi (ORCID: https://orcid.org/0000-0002-2370-7063)
- Anita D’Anselmo (ORCID: https://orcid.org/0000-0003-3940-2616)
- Andrea Pilotto (ORCID: https://orcid.org/0000-0003-2029-6606)
- Claudio Babiloni (ORCID: https://orcid.org/0000-0002-5245-9839)
- David Ondráček (ORCID: https://orcid.org/0000-0002-1193-1252)
- Sara Varanese
- Alberto Di Domenico (ORCID: https://orcid.org/0000-0002-9962-2891)
- Alberto Jaramillo-Jiménez (ORCID: https://orcid.org/0000-0001-5374-6410)
- G. Bruno (ORCID: https://orcid.org/0000-0001-6247-9633)
- Dag Aarsland (ORCID: https://orcid.org/0000-0001-6314-216X)
- Laura Bonanni (ORCID: https://orcid.org/0000-0001-7443-9233)
- Giulia Prete (ORCID: https://orcid.org/0000-0001-9969-6404)
- Nicola Mammarella (ORCID: https://orcid.org/0000-0003-1240-702X)
- Fabrizia D’Antonio (ORCID: https://orcid.org/0000-0002-0898-5938)
- Claudia Carrarini (ORCID: https://orcid.org/0000-0003-0718-9929)
- Adolfo Di Crosta (ORCID: https://orcid.org/0000-0002-8132-8985)
- Matteo Pardini (ORCID: https://orcid.org/0000-0002-4740-1982)
- Dario Arnaldi (ORCID: https://orcid.org/0000-0001-6823-6069)
- Milica Gregorič Kramberger (ORCID: https://orcid.org/0000-0001-8231-1176)
- Luca Tommasi (ORCID: https://orcid.org/0000-0003-0664-714X)
- John‐Paul Taylor (ORCID: https://orcid.org/0000-0001-7958-6558)
- Alessandro Padovani
- Lucrezia Bristot
Institutions
- University of Verona (IT)
- Marche Polytechnic University (IT)
- King's College London (GB)
- Università degli studi di Cassino e del Lazio Meridionale (IT)
- Masaryk University (CZ)
- Stavanger University Hospital (NO)
- Ljubljana University Medical Centre (SI)
- Universidad de Antioquia (CO)
- University of Chieti-Pescara (IT)
- Central European Institute of Technology – Masaryk University (CZ)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Ospedale Policlinico San Martino (IT)
- University of Brescia (IT)
- University of Genoa (IT)
- Newcastle University (GB)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1177/13872877251385424
- Primary Topic
- EEG and Brain-Computer Interfaces
- Type
- article
- Field-Weighted Citation Impact
- 0.00