Large-scale proteomic profiling identifies distinct inflammatory phenotypes in acute respiratory distress syndrome: a multicentre, prospective cohort study
We identified and validated three proteome-based acute respiratory distress syndrome phenotypes with distinct clinical, radiographic and molecular profiles. Their differential treatment responses highlight the potential of biomarker-driven strategies for acute respiratory distress syndrome precision medicine.
Authors
- Feng Shi (ORCID: https://orcid.org/0009-0006-1633-2175)
- Wei Pang (ORCID: https://orcid.org/0000-0003-3784-8067)
- Ruilan Wang (ORCID: https://orcid.org/0000-0001-9555-2649)
- Yuanlin Song (ORCID: https://orcid.org/0000-0003-3373-6631)
- Zhaocai Zhang (ORCID: https://orcid.org/0000-0002-4709-066X)
- Yumei Chen (ORCID: https://orcid.org/0000-0003-4756-4594)
- Jiancheng Zhang (ORCID: https://orcid.org/0000-0002-6103-7793)
- Cuiying Xie
- Xueling Wu (ORCID: https://orcid.org/0000-0002-3808-8381)
- Yiyu Deng (ORCID: https://orcid.org/0000-0002-0459-7399)
- Liying Zhan
- Lihong Huang (ORCID: https://orcid.org/0000-0003-1121-4859)
- W. R. Zhao (ORCID: https://orcid.org/0000-0001-5261-5910)
- Chengjin Gao (ORCID: https://orcid.org/0000-0002-6867-8024)
- Jianfeng Song (ORCID: https://orcid.org/0000-0002-6820-980X)
- Chen X. Chen (ORCID: https://orcid.org/0000-0002-6902-1227)
- Chenyang Dong
- Yannan Zhou
- Zhongshu Kuang (ORCID: https://orcid.org/0000-0003-2066-2696)
- Yun Xie (ORCID: https://orcid.org/0000-0002-4341-7426)
- Yiyan Lin (ORCID: https://orcid.org/0000-0002-4851-2502)
- Qi Liu (ORCID: https://orcid.org/0000-0002-9868-3705)
- Leilei Chen (ORCID: https://orcid.org/0000-0002-1987-3878)
- Yintao Wei (ORCID: https://orcid.org/0000-0003-0673-9095)
- Shen Yao (ORCID: https://orcid.org/0000-0001-5130-1928)
- Feixiang Xu (ORCID: https://orcid.org/0000-0001-6722-228X)
- Xiaoyu Fang (ORCID: https://orcid.org/0009-0006-3608-2863)
- Jing Zhu (ORCID: https://orcid.org/0000-0002-1646-2125)
- Mengna Lin
- Ran Ji
- Hailin Ding
- Su Lü
- Shuping Que
- Zhenju Song
- Lulu Lan
Institutions
- Shanghai University (CN)
- Union Hospital (HK)
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Renji Hospital (CN)
- XinHua Hospital (CN)
- Wuhan University (CN)
- Minhang District Central Hospital (CN)
- Zhongshan Hospital (CN)
- Pudong Medical Center (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- United Imaging Healthcare (China) (CN)
- Shanghai First People's Hospital (CN)
- Renmin Hospital of Wuhan University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Huazhong University of Science and Technology (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1183/13993003.00933-2025
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39