Targeting IL6-Edn1-FoxO1 axis enables lung growth in mechanically ventilated newborn mice
Mechanical ventilation causes an arrest of alveolarisation in newborn mice through an IL-6-mediated activation of Edn1 signalling and nuclear sequestration of FoxO1 in AT2. Thus, this study provides rationale for considering pharmacological inhibition of IL-6 and/or endothelin receptors as a therapeutic strategy for preterm newborns at risk of VILI-associated lung growth arrest.
Authors
- Oleksiy V. Klymenko (ORCID: https://orcid.org/0000-0003-0790-7054)
- Sana Mujahid (ORCID: https://orcid.org/0000-0003-2437-9409)
- Richard D. Bland
- Werner Seeger (ORCID: https://orcid.org/0000-0003-1946-0894)
- Jaco Selle (ORCID: https://orcid.org/0000-0002-4981-0931)
- Dharmesh Hirani (ORCID: https://orcid.org/0000-0002-3907-0917)
- Silke van Koningsbruggen-Rietschel
- Denise Al Alam (ORCID: https://orcid.org/0000-0003-3148-7352)
- Michele Donato (ORCID: https://orcid.org/0000-0002-9968-6027)
- Marlene Rabinovitch (ORCID: https://orcid.org/0000-0001-7886-7104)
- Thomas Wunderlich (ORCID: https://orcid.org/0000-0002-2203-7803)
- Christina Vohlen (ORCID: https://orcid.org/0000-0002-6395-7999)
- Miguel A. Alejandre Alcázar (ORCID: https://orcid.org/0000-0002-3176-0411)
- Manuel Koch (ORCID: https://orcid.org/0000-0002-2962-7814)
- Jennifer M. S. Sucre (ORCID: https://orcid.org/0000-0002-6613-1439)
- Virta Wagde (ORCID: https://orcid.org/0009-0005-9041-7495)
- Jörg Dötsch
- Stefanie Preuß
- Purvesh Khatri (ORCID: https://orcid.org/0000-0002-4143-4708)
- Soula Danopoulos (ORCID: https://orcid.org/0000-0002-2495-4445)
- Stefan Rose‐John (ORCID: https://orcid.org/0000-0002-7519-3279)
- Celien Kuiper-Makris (ORCID: https://orcid.org/0000-0002-7940-9612)
- Kerstin Wulf
- Mark Preuss
Institutions
- University of Cologne (DE)
- UCLA Medical Center (US)
- Christian-Albrechts-Universität zu Kiel (DE)
- Max Planck Institute for Heart and Lung Research (DE)
- Max Planck Institute for Metabolism Research (DE)
- German Center for Lung Research (DE)
- Universities of Giessen and Marburg Lung Center (DE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- University Hospital Cologne (DE)
- Cardio-Pulmonary Institute (DE)
- Institute of Infection and Immunity (CA)
- Harbor–UCLA Medical Center (US)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1183/13993003.01580-2024
- Citations
- 2
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04