RNF135 Expression Marks Chemokine (C-C Motif) Ligand-Enriched Macrophage–Tumor Interactions in the Glioblastoma Microenvironment
<i>RNF135</i> defines a TAM phenotype in GBM that is both immunologically active and immunosuppressive. This phenotype promotes inflammatory signaling and communication between cells in the tumor microenvironment. Targeting the CCL-CCR1 axis or combining <i>RNF135</i>-guided immunomodulation with certain inhibitors could be a promising therapeutic strategies for GBM.
Authors
- James J. Mulé (ORCID: https://orcid.org/0000-0001-7354-0516)
- Robert Macaulay (ORCID: https://orcid.org/0000-0003-1115-3654)
- Anders Berglund (ORCID: https://orcid.org/0000-0002-0393-3530)
- Arnold B. Etame (ORCID: https://orcid.org/0000-0002-9656-4702)
- Qiong Wu (ORCID: https://orcid.org/0000-0001-9712-0647)
- Jianan Chen (ORCID: https://orcid.org/0000-0002-6673-6884)
Institutions
- Moffitt Cancer Center (US)
- Université Bourgogne Franche-Comté (FR)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3390/cancers17193271
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80