Chemotherapy Liberates a Broadening Repertoire of Tumor Antigens for TLR7/8/9-Mediated Potent Antitumor Immunity
Our findings establish an antigen-centric mechanism underlying chemo-TLR agonist synergy: chemotherapy liberates a broadened repertoire of tumor antigens, which CR108 then leverages via innate immune activation to drive potent, T-cell-mediated antitumor immunity. This framework for rational selection of chemotherapy partners for TLR7/8/9 agonism and support clinical evaluation to convert "cold" tumors into immunologically responsive disease.
Authors
- Caizhen Zu (ORCID: https://orcid.org/0009-0007-3815-6528)
- Bin Wang (ORCID: https://orcid.org/0000-0002-9945-1818)
- Yiwei Zhong
- Shuting Wu (ORCID: https://orcid.org/0000-0001-7027-2392)
Institutions
- Fudan University (CN)
Publication Details
- Journal
- Cancers
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3390/cancers17193277
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Fudan University