The associations between Schistosoma mansoni infection, pre-treatment symptoms, praziquantel side effects, and treatment efficacy in Ugandan school-aged children
We show no evidence that being infected predisposes someone to side effects, nor that side effects are related to treatment efficacy. Relationships between pre-treatment infection intensity and pre-treatment symptoms or post-treatment side effects varied by school suggesting unmeasured factors such as co-infections or other health conditions could impact symptom and side effect reporting.
Authors
- Aidah Wamboko
- Annet Enzaru
- Annet Namukuta
- Moses Arinaitwe (ORCID: https://orcid.org/0000-0001-6340-465X)
- Edridah M. Tukahebwa (ORCID: https://orcid.org/0000-0002-0624-2890)
- Joanne P. Webster (ORCID: https://orcid.org/0000-0001-8616-4919)
- Poppy H. L. Lamberton (ORCID: https://orcid.org/0000-0003-1048-6318)
- Moses Adriko (ORCID: https://orcid.org/0000-0001-9748-1207)
- David Oguttu
- Narcis B. Kabatereine (ORCID: https://orcid.org/0000-0001-7036-5716)
- Jessica Clark (ORCID: https://orcid.org/0000-0003-1692-899X)
- Joaquín M. Prada (ORCID: https://orcid.org/0000-0003-4699-5931)
- Hsin-Su Yu (ORCID: https://orcid.org/0000-0002-3938-3446)
- Alan Fenwick
Institutions
- Royal Veterinary College (GB)
- University of Surrey (GB)
- Ministry of Health (UG)
- Imperial College London (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1371/journal.pntd.0013167
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00