Targeting sterol O-acyltransferase 1 rewires fatty acid metabolism and uncovers immune vulnerability in hepatocellular carcinoma
SOAT1 functions as both a metabolic vulnerability and an immune regulator in HCC. Its inhibition disrupts tumor-promoting metabolic processes while enhancing immune activation, presenting it as a promising therapeutic target. Combining SOAT1 inhibition with PD-1 blockade holds potential for improving outcomes in HCC immunotherapy.
Authors
- Daniel Wai‐Hung Ho (ORCID: https://orcid.org/0000-0003-3884-296X)
- Jingyi Lu
- Joyce Man‐Fong Lee
- Huanhuan Ma (ORCID: https://orcid.org/0000-0001-8029-6814)
- Christy Lai Ming Hui (ORCID: https://orcid.org/0000-0001-6912-208X)
- Fanhong Zeng (ORCID: https://orcid.org/0000-0001-9068-9048)
- Irene Oi‐Lin Ng (ORCID: https://orcid.org/0000-0001-7532-2029)
- Abdullah Husain (ORCID: https://orcid.org/0000-0003-0004-9974)
- Karen Man‐Fong Sze (ORCID: https://orcid.org/0000-0002-7997-5331)
- Eva Lee
- Xin Zhang (ORCID: https://orcid.org/0000-0002-8582-1128)
- Yu Man Tsui
- Huan Deng (ORCID: https://orcid.org/0000-0002-1596-2013)
Institutions
- University of Hong Kong (HK)
Publication Details
- Journal
- Hepatology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1097/hep.0000000000001561
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94