Reduced Shear Modulus and Altered Lamellar Morphology of the Outer Annulus Fibrosus in Painful Intervertebral Disc Degeneration Compared With Tissue From Non‐Surgical Controls
There were significant alterations in AF shear moduli and dynamic properties in DD individuals when compared to non-DD controls. Structural correlations highlight the role of the highly organized AF lamellar structure on shear modulus values. These findings suggest that altered AF mechanics may contribute to DD pathology and associated low back pain, warranting further investigation into structural and functional AF changes in symptomatic individuals.
Authors
- Paul Salo (ORCID: https://orcid.org/0000-0002-4005-9758)
- Lucas Lo Vercio (ORCID: https://orcid.org/0000-0002-5465-6801)
- Fred Nicholls
- Bradley Jacobs
- Ganesh Swamy (ORCID: https://orcid.org/0000-0002-3446-3105)
- David A. Hart (ORCID: https://orcid.org/0000-0001-8580-294X)
- Taylor J. Bader
- Manmeet S. Dhiman
- Jacques Bouchard
- Neil A. Duncan (ORCID: https://orcid.org/0000-0002-9782-3681)
Institutions
- University of Calgary (CA)
- Alberta Bone and Joint Health Institute (CA)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1002/jsp2.70123
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Sciences and Engineering Research Council of Canada