Palladium(II)‐Catalyzed Distal CH Functionalization of 8‐Aminoquinolinamides: Facile Synthesis of Triarylmethane Derivatives

Herein, a straightforward approach is reported for the palladium‐catalyzed oxidative remote CH alkylation of 8‐aminoquinoline derivatives using para‐ quinone methides. This method enables selective C5‐alkylation of quinolines and exhibits a site‐selectivity distinct from that typically observed in convetional palladium‐catalyzed sp 2 CH activation. The reaction proceeds via chelation‐induced remote CH functionalization, and a broad range of quinolinamides are successfully coupled with p ‐quinone methides, demonstrating excellent substrate scope and functional group tolerance. Preliminary mechanistic studies suggest a reversible CH metalation step as part of the catalytic cycle.