Cerebellar gray matter atrophy and altered structural covariance networks are associated with cognitive impairment in type 2 diabetes mellitus
By integrating VBM and SCN approaches, this study demonstrated that cerebellar GMV atrophy and abnormal structural covariance in T2DM were closely associated with cognitive dysfunction. These findings highlight the role of disrupted cerebro-cerebellar connectivity in the pathophysiology of T2DM-related cognitive impairment.
Authors
- Haitao Chu (ORCID: https://orcid.org/0000-0003-0932-598X)
- Jinyun Xue (ORCID: https://orcid.org/0000-0003-1584-9712)
- Dong Hu (ORCID: https://orcid.org/0000-0003-4281-9017)
- Shijun Qiu (ORCID: https://orcid.org/0000-0002-1840-0462)
- M D Long
Institutions
- Guangzhou University of Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fneur.2025.1626518
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China