Time-Intensity Curve parametric imaging as a novel quantitative biomarker: enhancing diagnostic accuracy and inter-rater reliability in prostate cancer ultrasound

TIC parametric imaging, through its ability to objectively quantify and visualize the spatial heterogeneity of tumor blood perfusion, serves as a powerful adjunctive tool that significantly enhances the accuracy and consistency of prostate cancer diagnosis. This technology demonstrates profound clinical value by substantially mitigating the influence of operator experience, thereby shortening the learning curve for novice physicians and standardizing diagnostic quality across all levels of expertise. the sample size is relatively small, which can lead to wide sensitivity confidence intervals and increases the risk of statistical anomalies. require validation in larger, multi-center prospective trials.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-10-09
DOI
https://doi.org/10.3389/fonc.2025.1644411
Primary Topic
Ultrasound and Hyperthermia Applications
Type
article
Field-Weighted Citation Impact
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article

Time-Intensity Curve parametric imaging as a novel quantitative biomarker: enhancing diagnostic accuracy and inter-rater reliability in prostate cancer ultrasound

Jiguang Zhou, Mingyou Liu, Xiao Yang, Hanzong Lin et al.
Frontiers in Oncology
Ultrasound and Hyperthermia Applications
article

Time-Intensity Curve parametric imaging as a novel quantitative biomarker: enhancing diagnostic accuracy and inter-rater reliability in prostate cancer ultrasound

Jiguang Zhou, Mingyou Liu, Xiao Yang, Hanzong Lin, You Lang Zhou, Jinxin Lan, Yusheng Xu, Ming Chen
article en

Abstract

TIC parametric imaging, through its ability to objectively quantify and visualize the spatial heterogeneity of tumor blood perfusion, serves as a powerful adjunctive tool that significantly enhances the accuracy and consistency of prostate cancer diagnosis. This technology demonstrates profound clinical value by substantially mitigating the influence of operator experience, thereby shortening the learning curve for novice physicians and standardizing diagnostic quality across all levels of expertise. the sample size is relatively small, which can lead to wide sensitivity confidence intervals and increases the risk of statistical anomalies. require validation in larger, multi-center prospective trials.

Frontiers in OncologyVol. 15
Fujian Medical University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking Union Medical College Hospital (CN), Zhangzhou Municipal Hospital of Fujian Province (CN)
Openalex Percentile: Top 73%
Ultrasound and Hyperthermia Applications
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