Time-Intensity Curve parametric imaging as a novel quantitative biomarker: enhancing diagnostic accuracy and inter-rater reliability in prostate cancer ultrasound
TIC parametric imaging, through its ability to objectively quantify and visualize the spatial heterogeneity of tumor blood perfusion, serves as a powerful adjunctive tool that significantly enhances the accuracy and consistency of prostate cancer diagnosis. This technology demonstrates profound clinical value by substantially mitigating the influence of operator experience, thereby shortening the learning curve for novice physicians and standardizing diagnostic quality across all levels of expertise. the sample size is relatively small, which can lead to wide sensitivity confidence intervals and increases the risk of statistical anomalies. require validation in larger, multi-center prospective trials.
Authors
- Jiguang Zhou
- Mingyou Liu (ORCID: https://orcid.org/0000-0003-0393-8697)
- Xiao Yang (ORCID: https://orcid.org/0000-0003-0437-2015)
- Hanzong Lin
- You Lang Zhou (ORCID: https://orcid.org/0000-0003-0465-5509)
- Jinxin Lan (ORCID: https://orcid.org/0009-0002-0022-9641)
- Yusheng Xu
- Ming Chen (ORCID: https://orcid.org/0009-0007-3572-1579)
Institutions
- Fujian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Zhangzhou Municipal Hospital of Fujian Province (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fonc.2025.1644411
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00